I can tell you one thing that no longer exists in my world due to my use of psychoactive drugs.
I no longer have hangovers.
While a long day/ night of drinking will still usually result in a slightly nauseated upset stomach and achy muscles the next day, I do not experience a crippling light and sound sensitive headache that I used to wake up with rather regularly.
The reason is Lithium.
There are many people that speculate as to why lithium is not more widely prescribed for various ailments, chiefly among them is that lithium cannot be patented so there is no money to develop or market it properly. But the reality is that lithium is something of a super drug. The last fifteen years or so have provided the largest and widest scope of medical testing in the history of lithium and the results are stunning, even if unproven at this point.