There has been a significant development in the treatment of resistant depression.
Things have basically come to a stand-still in the treatment of people with deep depression that is resistant to drugs. As of right now, there are three options: drugs, ECT or other intra-cranial electrical stimulation, or cognitive behavioral therapy (or other forms of therapy that are coming into more common use). Drugs have a low efficacy rate, leaving a huge portion of patients to other options. ECT is considered dangerous and a lot of people opt-out of the treatment. Therapy alone can do a lot but cannot handle the severe and dangerous highs and lows.